Equipment for the pharmaceutical industry - Import export

The task of storing liquids hazardous to water or to their processing must be handled responsibly. In the building of the corresponding process containers, storage tanks, stainless steel containers, different factors must be taken into consideration. They are designed according to regulations, such as PED (AD-2000, SVTI, EN13445) or according to special standards, such as the Basel chemical standard BN76 and manufactured in stainless steel. Process containers and storage tanks have half-pipe coils, jackets or laser-welded structures (pillow plates) for heating and cooling purposes. KASAG is the competent place if you are looking for replacement, modification, extension or reconstruction of complete tank plants. We will share your responsibilities.

Pressure vessels, reactors, Pharmaceutical and biotech pressure vessles, Process containers, storage tanks, Modules, components, plants, High-pressure apparatuses,Heat exchangers, vaporisers, condensers, Cryo pressure vessels, technologies Nuclear technology, Vacuum chambers, vacuum apparatuses, Columns, according to PED (EN13445 / AD-2000), ASME (U-Stamp), China Stamp (A1), TP TC 032/2013 (EAC) Pharmaceutical and biotech apparatuses are calculated and manufactured according to your requirements. Stainless steel and special materials are used in the production. After that, the products are grinded, electropolished and tested using non-destructive testing methods, such as ferrite measurements, used for the determination of the ferrite content, or by using the riboflavin test to measure total discharge and CIP/SIP capability. All materials, methods and processes used have been documented in full in detailed QA documents and can be tracked at any time. You can depend on KASAG.

Glass pilot reactor and pilot plant Glass reactor: 15, 30, 60 liter Pressure: -1.0 (FV) to +0.5 bar Temperature: -60 °C (-90 °C) to +200 °C Material: Borosilicate glass 3.3, glass-lined steel, PTFE, PFA, tantalum A clean-room setup and other materials are available to meet your specific process requirements. Performance and reliability are key issues in the explosion proof design of Buchi glass reaction systems. The inert materials allow safe processing in an inert atmosphere of a wide range of solvents and acids in a completely sealed glass reaction system under full vacuum. Multiple chemical reaction steps are performed safely in the same setup. The system consists of: Reactor, solid jacketed full view glass reactor to easily improve and control chemical reactions by visual observation Distillation glass overhead built with buchiflex components (unique flexible ball - socket joints) for mulitple, reliable processes under full vacuum

Glass overheads are typically built (in our standard chemReactor and production plant setups) for multipurpose and semi–batch operation mode under full vacuum. They mostly consist of feeder vessel, a distillation column, condenser and secondary condenser, phase separator, receiver, including valves and pressure equalization piping and a rupture disc as safety device. For rectification, packed distillation glass columns up to DN600 are used with reflux condenser, a reflux splitter with a reflux controller to set the reflux ratio. In Buchi chemReactors, both systems can be combined.

The temperature of jacketed reactors can be controlled by TCUs (temperature control unit) large central heating/cooling units with secondary systems for individual reactor temperature control process steam (in case of large metal reactors) Our jacketed reactors are typically temperature controlled using heat transfer oil and TCU or central heating/cooling units. The heat transfer oil which is pumped through the jacket of the reactor controls the process temperature inside the reactor. The temperature range of the heat transfer oil spans from -80°C up to 300°C (depending on the heat transfer oil used).

Pressure reactor for kilo labs and small-scale production Reactor volume: 20 to 500 liter Pressure: -1 (FV) to +200 bar Temperature: -20 °C to +300 °C Material: stainless steel, Hastelloy® Other materials, pressures & temperatures are available Buchi pilot plants are built for pressure reactions as well as for reactions under full vacuum. Different technologies and materials are used, depending on the requested process and process media. Pilotclave pressure reactors range from 50 - 500 liter and are all customized. To quote such systems we require detailed specifications. Safety is important with such larger scale systems, especially when doing hydrogenations and other reactions under higher pressure. The degree of automation and process control vary from simple data collection to complete automation of the system. In most cases, the reaction vessels are jacketed steel or Hastelloy® reactors.

Catalyst testing, catalyst screening Catalyst testing covers several types of research such as catalyst effectiveness, yield, activation, lifetime and regeneration. The type of catalyst baskets varies depending on the catalyst being used, the interaction with the chemistry, the temperature, the pressure and the number of catalysts in the basket. Exposure to the reactants can be done through a stationary catalyst bed or a spinning basket. Our special accessories offer solutions for more complex problems in pressure reactions in the field of catalyst research.

Probes for process control Probes are available to measure the different process parameters. These values can be displayed on our monitoring instrument and recorded in our bls software, see measure & control. Frequently measured parameters are: temperature pressure stirrer speed torque pH IR probes, probes to control particle sizes etc. from other suppliers can be integrated into our pressure reactors or stirred autoclaves.

Feeding of liquids, solid, gas Burettes Volume: 10 - 1000 ml Pressure: depending on material Material: Glass, stainless steel, Hastelloy® Burettes are available in glass with protective jacket or as full metal version for higher pressures with sightglass. Feeding funnels enable fast charge of solids and liquids.

Glass distillation columns up to DN 600 are packed with random packing such as Raschig rings, ceramic saddles, PFA packing elements or structured packing dependent on the required separation performance and process media. Each packing type shows different separation performance, indicated by their number of theoretical stages. In combination with glass process equipment, highly corrosion resistant packing material is used for packed glass distillation columns.

Laboratory pressure reactor system - easy operation for heavy pressure vessels Reactor volume: 0.5 to 20.0 liter Pressure: -1 (FV) to +60 / 200 bar Temperature: -20 °C to +250 °C Material: stainless steel, Hastelloy®, glass-lined steel Other materials, pressures & temperatures are available This multipurpose pressure reactor system is designed for the use of large steel pressure vessels. The hydraulic vessel lift with tilt function makes opening and closing as well as cleaning of the vessel very easy. Safety features guarantee safe reactions under pressure. The stainless steel or Hastelloy® reactors ensure high resistance against acids. Visual process control and monitoring is also possible under high pressure by using steel pressure vessels with sight glasses. Various low to high torque magnetic drives ensure efficient mixing and stirring low to high viscosity process media as well as excellent heat transfer.

Nutsche filters for reactors and pilot plants Glass vessel: 10, 30, 50, 100, 140, 300 liter Pressure: -1.0 (FV) to +0.5/ 1.0 bar Temperature: -60 °C to +200 °C Filter cloth: Mesh size 8 to 115 micron Material: Borosilicate glass 3.3, PTFE, PFA, ETFE A clean-room setup and other materials are available to meet your specific process requirements. Buchi nutsche filters can easily be combined with our reactors for solid / liquid separation after the synthesis. The inert materials allow safe processing in an inert atmosphere of a wide range of solvents and acids in a completely sealed (buchiflex) glass system under full vacuum. The slurry is transferred into the filter. The solid content in the slurry is held back by the filter cloth forming a filter cake, while the filtrate runs away to the outlet valve in the bottom plate. The filtering stage ends when the filtrate is of small quantity, which can be shortened by squeezing the filter cake by turning the height adjustable stirrer.

Customized parallel pressure reactor system Reactor volume: 50 ml - 300 ml Number of reactors: 2 - 6 Pressure: -1.0 (FV) to +150 bar Temperature: -20 °C to +300 °C Material: stainless-steel, Hastelloy®, tantalum, PTFE inliner Other setups are available. Catalyst screening and Hydrogenations in reduced time, reproducible and safe: These were the key issues for our customer in chemical research, asking us to develop this system. This parallel pressure reactor system is configurable and modular, allowing for individual or parallel operation settings of each reactor. This system uses automated process control enabling fast process development and parallel reaction screening in a reproducible and safe manner. Multiple safety features guarantee safe hydrogenations and other processes.

With the miniPilot product family (reactor, nutsche filter, scrubber) we offer miniplant pilot reactors for chemical process development, scale-up, process simulation and kilo-scale production. The reactors' explosion proof design (ATEX) and inert materials allow safe processing of solvents and acids in a completely sealed reaction vessel. The compact standard reactor setup can easily be modified, interchangeable reaction vessels of 5, 10 and 15 liter including interchangeable stirrers are available. The reaction vessel is installed on a lifting / lowering device to simplify opening and cleaning. The distillation glass overhead is built with flexible ball-socket joints for multiple chemical reactions under full vacuum. A clean-room setup and other materials are available to meet your specific process requirements.

Glass reactor: 20 to 30 liter Pressure: -1.0 (FV) to +0.5 bar Temperature: -60 °C (optional -90 °C) to +200 °C Material: Borosilicate glass 3.3, PTFE, PFA, PEEK The midiPilot is our sturdy multipurpose glass reactor for small volumes. It is specifically designed for applications in kilo lab, for chemical process development and cGMP compliant API syntheses. A clean-room setup and other materials are available to meet your specific process requirements. A clean-room setup and other materials are available to meet your specific process requirements.

High-performance reactor systems for API synthesis, small scale production and pilot plant applications Glass, glass-lined steel reactor: 15, 30, 60, 100, 160, 250 liter Pressure: -1.0 (FV) to +0.5 bar Temperature: -60 °C (-90 °C) to +200 °C Material: Borosilicate glass 3.3, glass-lined steel, PTFE, PFA, tantalum A clean-room setup and other materials are available to meet your specific process requirements. Performance and reliability are key issues in the explosion proof design of Buchi glass reaction systems: The inert materials allow safe processing in a inert atmosphere of a wide range of solvents and acids in a completely sealed glass reaction system under full vacuum. Multiple chemical reaction steps are performed safely in the same setup. The system consists of:

Basic glass reactor systems for API synthesis, small scale production and pilot plant. Glass reactor: 15, 30, 60 liter Pressure: -1.0 (FV) to +0.5 bar Temperature: -60 °C (-90 °C) to +200 °C Material: Borosilicate glass 3.3, glass-lined steel, PTFE, PFA, Tantalum A clean-room setup and other materials are available to meet your specific process requirements. Performance and reliability are key issues in the explosion proof design of Buchi glass reaction systems. The inert materials allow safe processing in an inert atmosphere of a wide range of solvents and acids in a completely sealed glass reaction system under full vacuum. Multiple chemical reaction steps are performed safely in the same setup. The system consists of: Solid jacketed full view glass reactor to easily improve and control reactions by visual observation Distillation glass overhead built with buchiflex components (unique flexible ball - socket joints) for multiple, reliable processes under full vacuum

Mobile gas scrubber (volume scrubbing liquid) : 6, 10, 20, 50, 100 liter Mobile gas scrubber (column diameter): DN 50, 70, 100, 150, 200 Stationary gas scrubber (volume scrubbing liquid) : Customized according to process requirements Stationary gas scrubber (column diameter): DN50 up to DN600 Pressure: -1.0 (FV) to +0.5 bar Temperature exhaust gas: -60 °C to +200 °C Temperature scrubbing liquid: 0 °C to +80 °C Material: Borosilicate glass 3.3, PTFE, ETFE Gas scrubbers are used to neutralize corrosive exhaust gas from reactors. Depending on the scrubbing liquid, they can be used for caustic or acidic vapors. Gas scrubbers are equipped with an ETFE lined, corrosion resistant magnetic coupled pump. The flow rate of the scrubbing liquid can be controlled with the built-in reducing valve. The scrubbing liquid temperature is maintained by a spiral cooler in the liquid circuit.

We offer various solutions for liquid dosing. Based on parameters such as flow rate, dosing accuracy, properties of the media process and regulatory requirements we select the appropriate method of dosing as well the most suitable dosing instruments. Dosing methods used, include gravimetric dosing with load cells, various types of dosing pumps and dosing with pumps using mass flow controller (MFC) and level sensors.

Most processes in glass reactors are performed under vacuum. We cooperate with the leading manufacturers of vacuum pumps with the aim to supply complete reactions systems (reactor plus vacuum pumps). This cooperation guarantees best process performance due to the optimal configuration of reactor and vacuum pumps.

Reactor volume: 0.5 to 1.0 liter Pressure: -1 (FV) to +60 bar Temperature: - 20 °C to +250 °C Material: Borosilicate glass 3.3, stainless steel This multipurpose pressure reactor system is designed for the use of interchangeable glass and steel pressure vessels. Safety features guarantee safe reactions under pressure. The polycarbonate door of the uniclave housing also allows glass pressure reactors up to 12 bar to be used safely and with unrestricted visibility. The high-torque magnetic stirrer drive offers you optimal control of mixing tasks with the display of speed and torque. The glass reactors ensure high resistance against acids, while allowing visual process control and monitoring. The modular setup of the uniclave system allows changing of the vessel or upgrading of the configuration for new tasks at any time.

Laboratory pressure reactor system - comfortable and simple operation Reactor volume: 0.25 to 5.0 liter Pressure: -1 (FV) to +60 / 200 bar Temperature: -20 °C to +250 °C Material: Borosilicate glass 3.3, stainless steel, Hastelloy® Other materials, pressures & temperatures are available. This multipurpose pressure reactor system is designed for the use of interchangeable glass and steel pressure vessels. Safety features guarantee safe reactions under pressure. The glass reactors ensure high resistance against acids, while allowing visual process control and monitoring. This is also possible under high pressure by using steel pressure vessels with sight glasses. Various low to high torque magnetic drives ensure efficient mixing and stirring low to high viscosity process media as well as excellent heat transfer. The modular setup of the polyclave system allows changing or upgrading for new tasks at any time.

Laboratory pressure reactor system - for pressure reactions in metal pressure vessels Reactor volume: 0.5 to 5.0 liter Pressure: -1 (FV) to +60 / 200 bar Temperature: -20 °C to +250 °C Material: stainless steel, Hastelloy® Other materials, pressures & temperatures are available This multipurpose pressure reactor system is designed for the use of interchangeable steel pressure vessels. Safety features guarantee safe reactions under pressure. The stainless steel or Hastelloy® reactors ensure high resistance against acids. Visual process control and monitoring is also possible under high pressure by using steel pressure vessels with sight glasses. Various low to high torque magnetic drives ensure efficient mixing and stirring low to high viscosity process media as well as excellent heat transfer.

Laboratory pressure reactor system Reactor volume: 10 to 25 ml Pressure: -1 (FV) to +10 / 100 bar Temperature: -20 °C to +200 / 300 °C Material: Borosilicate glass 3.3, stainless steel, Hastelloy®, PTFE Other materials, pressures & temperatures are available. This pressure reactor system is designed for the use of interchangeable pressure vessels in glass, steel, Hastelloy®, Teflon. Safety features guarantee safe reactions under pressure. The glass pressure reactors ensure high resistance against acids, while allowing visual process control and monitoring.

Universal glass reactor / Metal laboratory pressure reactor Reactor volume: 100 to 300 ml Pressure: -1 to +150 bar Temperature: -20 °C to +300 °C Material: Borosilicate glass 3.3, stainless steel, Hastelloy® Other materials, pressures & temperatures are available. This multipurpose pressure reactor system is designed for the use of interchangeable glass and steel pressure vessels. Safety features guarantee safe reactions under pressure. The glass reactors ensure high resistance against acids, while allowing visual process control and monitoring. It is also possible to use steel pressure vessels for high pressure reactions. The magnetic drive ensures efficient mixing and stirring of the process media as well as excellent heat transfer. The Fast Action Closure makes changing vessels quick and easy without the use of tools.

Laboratory high pressure reactor system Reactor volume: 0.1 - 1.0 liter Pressure: -1 (FV) to +200 bar Temperature: -20 °C to +300 °C Material: stainless steel, Hastelloy® Other materials, pressures & temperatures are available This high pressure reactor system is designed for the use of interchangeable steel pressure vessels. Safety features guarantee safe reactions under pressure. The stainless steel or Hastelloy reactors ensure high resistance against acids. Visual process control and monitoring is also possible under high pressure by using steel pressure vessels with sight glasses. Various low to high torque magnetic drives ensure efficient mixing and stirring low to high viscosity process media as well as excellent heat transfer. The fast action closure and vessel lift makes changing vessels quick and easy without the use of tools. The modular setup of the midiclave system allows changing or upgrading for new tasks at any time.

Laboratory high pressure / high temperature reactor (HPHT) Standard Version: Reactor volume: 100 - 600 ml Pressure: -1 (FV) to +400 bar Temperature: -20 °C to + 400 °C Material: stainless steel, (Hastelloy® +400 °C) High-Pressure Version: Reactor volume: 100 - 600 ml Pressure: -1 (FV) to +500 bar Temperature: -20 °C to + 500 °C Material: stainless steel, (Hastelloy® +400 °C) This is our new high pressure and high temperature HPHT (high pressure high temperature) autoclave novoclave. This high pressure reactor system is designed for processes involving high pressures and temperatures. Safety features guarantee safe reactions under highest pressure. Designed, manufactured, and tested according to PED, AD2000. The modular setup of the novoclave system allows for changing the vessel size from 100 ml up to 600 ml using the same cover plate and electric heating block. Vessels are available in the following volumes: 100, 200, 300, 450, 600 ml.

Laboratory high pressure reactor system Reactor volume: 0.5 - 5.0 liter Pressure: -1 (FV) to +350 bar Temperature: -20 °C to +350 °C Material: stainless-steel, Hastelloy® Other materials, pressures & temperatures are available. This high pressure reactor system is designed for the use of interchangeable steel pressure vessels. Safety features guarantee safe reactions under pressure. The stainless steel or Hastelloy® reactors ensure high resistance against acids. The high torque magnetic drive ensures efficient mixing and stirring of the process media as well as excellent heat transfer. The system is equipped with a lifting device for vessel and electric heating. The modular setup of the limbo ls system allows changing or upgrading for new tasks at any time.

Inert laboratory pressure reactor system Reactor volume: 100 - 300 ml Pressure: -1 (FV) to +10 bar Temperature: -20 °C to +150 °C Material: Borosilicate glass 3.3, PTFE, PFA, FEP Special executions are available. This metal - free pressure reactor system is designed for the use of interchangeable glass pressure vessels. All product touched parts are made of inert (non-metallic) materials. Safety features guarantee safe reactions under pressure. The glass reactors ensure high resistance against acids, while allowing visual process control and monitoring. A wide range of accessories is available – talk to us to define the right setup for your specific need.