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The IST AG LV5 sensor is a flow-through biosensor and offers the possibility for multi-parametric measurements, since up to 4 analytes can be measured simultaneously (glucose, lactate, glutamine, glutamate). The sensor features a very small flow cell (1 µL) and therefore requires minimal sample volumes when used as an analyzer. Further advantages of the LV5 biosensor include: — Excellent long-term stability over a month in continuous measurement mode (lifetime varies depending on various factors, including the analyte concentration and buffer system (medium) amongst others) — Long shelf life (under appropriate environmental conditions) — Gamma and beta sterilization compatible — Suitable for continuous and analyzer measurement modes — Fast response time (depends on the buffer system (medium)) — Reference, counter and blank electrodes on-chip — Integrated flow cell (various volumes) Suitable for sampling systems in laboratories or food and pharmaceutical industries.

Automation solution to perform medical sample analysis in diagnostic laboratories. Automatic sample distribution system transports the samples directly to the appropriate analysis system

Medical Device Services / Medical Device Laboratory Testing INVITRO-CONNECT GmbH offers you: - General regulatory advice for medical devices - All regulatory examinations and tests under GLP - Project management and study monitoring - Medical Device Regulatory Service - Product testing for contained SVHC substances INVITRO-CONNECT offers you a complete service for the approval of medical devices according (EU) 2017/745 (Medical Device Regulation - MDR) / ISO 10993. From the development of an ideal test strategy to laboratory and project coordination, study monitoring, toxicological expertise and GLP inspections in the cooperation laboratories. We deliver the finalized test reports including the registration dossier - digitally and on paper, worldwide. Benefit from our diverse know-how, our experienced cooperation partners and an international, very well-organized network. Questions? -> contact@invitro-connect.com

INVITRO-CONNECT GmbH offers various test strategies without animal testing for examining Eye Irritation / Eye damage hazard assessment. From standard regulatory hazard assessments to providing information on the degree of ocular irritation, to discriminating among extremely mild eye area products, INVITRO-CONNECT’ Study Monitors take the time to understand your specific goals and apply the most relevant, cost-effective strategies to achieve them. Tests for Eye Irritation / Eye damage hazard assessment in vitro: HET-CAM Assay BCOP: OECD 437 Isolated Chicken Eye Test: OECD 438 STE / Short Time Exposure (STE, OECD 491): Ocular Irritection EpiOcular & SkinEthic HCE Reconstructed human Cornea-like Epithelium (RhCE): OECD 492 For more information please contact INVITRO-CONNECT GmbH for assistance in developing specialized protocols for your test materials. INVITRO-CONNECT GmbH: Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com

Material Safety Data Sheet - Hazardous Substances Advice and Hazardous Substance Management Overview of our services: - Check of conformity and plausibility as well as updating of existing Material Safety Data Sheets - Preparing of extended Material Safety Data Sheets - Classification and labelling of substances according to the current GHS regulation (CLP regulation) Depend on requirements INVITRO-CONNECT GmbH checks whether your existing safety data sheets are still compliant and plausible to follow latest REACH guidelines and if necessary, updates them for you. Furthermore, based on our know-how we provide extended material safety data sheet, following the REACH Directive as well as the latest European GHS regulation for classification and labelling of substances. INVITRO-CONNECT GmbH - Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com Best regards Pascal Piller and Dr. Ute Hassmann and the whole team of INVITRO-CONNECT GmbH

Our experts support you with the following services: - Toxicological assessment within the framework of the REACH and biocide regulations - Environmental Risk Assessment (ERA = Environmental Impact Assessment), e.g. for pharmaceuticals - Literature research and evaluation - Examination of the reliability and validity of the studies carried out (according to OECD guidelines, EU methods or according to Klimisch et al. 1997) - Assessment of relevant toxicological endpoints, e.g. acute toxicity, genotoxicity, irritation / corrosion of the skin or eyes - Evaluation of all relevant toxicological, ecotoxicological endpoints, e.g. freshwater organisms (daphnia, algae, fish) - Read Across - Study monitoring of studies - Creation of the Endpoint Summaries and Endpoint Study Records for IUCLID (REACH and biocidal active ingredients and products) - Safety assessment and safety report for cosmetic products - Water hazard class - etc. Questions?--> contact@invitro-connect.com

INVITRO-CONNECT GmbH is your ideal partner and service provider for your projects in the field of life science for chemicals / REACH, pharmaceuticals, biocides, cosmetics and medical devices. We are the strong partner at your side who provides our tailor-made service modules according to your project requirements. You have the choice to individually select the modules that you urgently need in your projects from our modular service system. With our technical expertise and our customer-oriented approach, we fit in perfectly with your projects and processes, so that we form a team and nothing stands in the way of the project's success. The Modules can be individually and flexibly adapted for each project. For more information please contact INVITRO-CONNECT GmbH. INVITRO-CONNECT GmbH - Your International Experts for Laboratory Testing and Regulatory Services Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com

Testing against enveloped viruses as a replacement for the currently unavailable commercial test strategy against 2019-nCov / SARS-CoV-2 Since the new SARS-CoV-2 virus is one of the enveloped viruses, INVITRO-CONNECT GmbH offers testing of various surfaces and disinfectants against the Vaccinia Ankara Virus (MVA) as a reference virus for enveloped viruses, as well as against the bovine coronavirus , which, like SARS-CoV-2, belongs to the genus Betacoronavirus. In addition to standard tests for surfaces in accordance with ISO 21702 (smooth surfaces) and ISO 18184 (rough surfaces) as well as suspension tests for the disinfectant area (EN ISO 14476/16777), other tests are also offered on request (see below). Named tests are currently the state-of-the-art test methods for testing against 2019-nCov / SARS-CoV-2, as there is currently no specific test procedure against the 2019-nCov / SARS-CoV-2 virus itself. For more information --> contact@invitro-connect.com

Microbiological examinations / Microbiological tests against viruses, bacteriophages, bacteria, yeast, molds, mycobacteria and bacterial spores for disinfectants, medical devices, pharmaceutical products and cosmetics Our team of experts supports manufacturers of biocidal and medical products as well as cosmetics and pharmaceuticals scientifically in the context of approval projects. For example, we create safety assessments for cosmetics and biocompatibility assessments for medical devices. Here we focus in particular on infection prevention and wound treatment products. For more information please contact INVITRO-CONNECT GmbH for assistance in developing specialized protocols for your test materials. INVITRO-CONNECT GmbH: Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com

- in vitro gene mutation study in bacteria: Ames Test OECD 471 - in vitro gene mutation study in mammalian cells: Mouse Lymphoma Assay (MLTK Assay) OECD 490 - in vitro gene mutation study in mammalian cells: HPRT test / OECD 476 - Micronucleus Assay in vitro (Human Lymphocytes or V79 cells) / OECD 487 - Chromosomal aberration Assay in vitro (Human Lymphocytes or V79 cells) / OECD 473 - Hen’s Egg Test – Induction of Micronuclei (HET-MN) - COMET Assay in different cell types - Cell Transformation Assay in Bhas Cells / OECD 231 (draft) - Mammalian Erythrocyte Micronucleus Test / OECD 474 / ISO 10993-3 - Combined Mammalian Erythrocyte Micronucleus Test with concurrent Alkaline Comet Assay in vivo OECD 474 & 489 - In vivo Mammalian Alkaline Comet Assay / OECD 489 - Unscheduled DNA synthesis (UDS) Test with Mammalian Liver Cells in vivo / OECD 486 - Mammalian Spermatogonial Chromosomal Aberration test / OECD 483 - Mammalian Bone Marrow Chromosomal Aberration test / OECD 475

- OECD 439 / Skin Irritation Test (SIT) in a Reconstructed Human Epidermis (RhE) Model - Skin Irritation in the regulatory hazard classification and labeling context is defined as the production of reversible damage to skin following a defined chemical exposure. The Skin Irritation Test (SIT) is an in vitro, non-animal test designed to identify those chemicals and mixtures capable of inducing moderate skin irritation (UN GHS Category 2 Skin Irritants1), and to discriminate UN GHS Category 2 Skin Irritants from UN GHS 3 Mild Skin Irritants as well as those not requiring classification for skin irritation potential. INVITRO-CONNECT GmbH has extensive expertise with a wide variety of reconstructed skin-based protocols. For more information please contact INVITRO-CONNECT GmbH for assistance in developing specialized protocols for your test materials. INVITRO-CONNECT GmbH: Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com

- OECD 431 - Human Skin Corrosion: "In Vitro OECD 431: Reconstructed Human Epidermis Test Method, in vitro Test - Skin Corrosion in the regulatory hazard classification and labeling context is defined as the production of irreversible damage to skin, generally evident as necrosis through the epidermis and into the dermis, following a defined chemical exposure. The In Vitro Skin Corrosion Test is an in vitro, non-animal test designed to identify those chemicals and mixtures capable of inducing skin corrosion (UN GHS Category 11), and in some cases to partially subcategorize corrosives into UN GHS Sub-Categories 1A or 1B and 1C (ie., the current test methods do not effectively discriminate between UN GHS Sub-Categories 1B and 1C). For more information please contact INVITRO-CONNECT GmbH for assistance in developing specialized protocols for your test materials. INVITRO-CONNECT GmbH: Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com

INVITRO-CONNECT GmbH offers various test strategies without animal testing for examining Eye Irritation / Eye damage hazard assessment. From standard regulatory hazard assessments to providing information on the degree of ocular irritation, to discriminating among extremely mild eye area products, INVITRO-CONNECT’ Study Monitors take the time to understand your specific goals and apply the most relevant, cost-effective strategies to achieve them. Tests for Eye Irritation / Eye damage hazard assessment in vitro: HET-CAM Assay BCOP: OECD 437 Isolated Chicken Eye Test: OECD 438 STE / Short Time Exposure (STE, OECD 491): Ocular Irritection EpiOcular & SkinEthic HCE Reconstructed human Cornea-like Epithelium (RhCE): OECD 492 For more information please contact INVITRO-CONNECT GmbH for assistance in developing specialized protocols for your test materials. INVITRO-CONNECT GmbH: Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com

Determination of skin sensitization potential is a critical endpoint in the safety assessment of raw materials, chemicals, mixtures and formulations. Although the Guinea Pig Maximization Test (GPMT) and Local Lymph node assay (LLNA) have historically been used to address this adverse effect, in vitro assays have been developed and validated in order to replace these resource-intensive animal tests. INVITRO-CONNECT GmbH offers various test strategies without animal testing for examining skin sensitization: - Direct Peptide Reactivity Activation Assay (DPRA, OECD 442C) - ARE-Nrf2 Luciferase Keratinocyte Activation Test Method (OECD 442D) -Human Cell Line Activation Test (h-CLAT, OECD 442E) -Kinetic Direct Peptide Reactivity Assay (kDPRA) -Myeloid U937 Skin Sensitization Test (MUSST / U-SENS) -and more Fast Project Execution: personal - competent - reliable --> contact@invitro-connect. - More than 80 Test Laboratories - Product Safety - Regulatory Service -

INVITRO-CONNECT GmbH offers various test strategies without animal testing for examining skin Corrosion: - OECD 435 - Skin Corrosion : "In Vitro Membrane Barrier Test Method for Skin Corrosion" (Corrositex): The Corrositex® assay is a standardized and quantitative in vitro test developed as a replacement for the dermal corrosivity rabbit test. The Corrositex® assay is presently the only in vitro assay approved by the U.S. Department of Transportation for testing potential corrosive materials and assigning packing group categories. For more information please contact INVITRO-CONNECT GmbH for assistance in developing specialized protocols for your test materials. INVITRO-CONNECT GmbH: Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com More than 80 test laboratories - Product safety - Regulatory service - In vitro tests - All OECD tests for pharmaceuticals, chemicals, medical devices and cosmetics - Study monitoring, MSDS etc.

https://www.invitro-connect.com/en - Your International Experts for Laboratory Testing and Regulatory Services - More than 80 test laboratories in our network - Product safety - Regulatory service - in vitro tests - All OECD tests for pharmaceuticals, chemicals, medical devices and cosmetics - in-house toxicologistes - Project management - Study monitoring --> complete services - all from one hand !!! --> contact@invitro-connect.com We would like to manage also your projects. Best regards Pascal Piller and the whole team of INVITRO-CONNECT GmbH #biocides #toxicological #chemicals #laboratory #regulatory #affairs #reach #projectmanagement #pharma #medical #study #devices #Labor #GLP #cosmetics

We offer you the following services: - Regulatory Advice - REACH Registration - Preparation of Registration Dossiers - Read Across - IUCLID - Robust Study Summaries - Chemical Safety Report / CSR - Toxicological Expertise - Optimal Test Strategy Development - REACH Testing: Tests and Studies acc. GLP - REACH Study Monitoring - SVHC Screening - Risk Assessment - REACh Compliance Service / REACh Auditing Service - REACH Material Safety Data Sheets We would also be happy to be your REACH service provider, who reliably looks after your REACH projects, just as we already do for many other satisfied customers. For more information please contact INVITRO-CONNECT GmbH. Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com REACH Service - All REACH laboratory tests - Phys-Chem / Tox / in vitro tests / Genotox / Ecotox, etc. - More than 80 test laboratories - Study monitoring, Regulatory Service, IUCLID 6, CSR etc.

INVITRO-CONNECT GmbH: - Regulatory advice - All OECD laboratory tests - Phys-Chem / Tox / in vitro tests / Genotox / Ecotox, E-fate etc. - Personal project management - in-house toxicologists - Study monitoring - Study Summaries, IUCLID 6 - Dossier creation - MSDS etc. Benefit from an international, very well organized network: carefully selected experts, in-house toxicologists and more than 80 accredited test laboratories and service providers with over 20 years of experience in the industry. We are your competent partner for regulatory and toxicological issues, expert services, reports and all OECD laboratory tests We are also happy to be your reliable partner for your laboratory services and regulatory projects. Questions? -> contact@invitro-connect.com Your Mrs. Dr. Ute Hassmann and Your Mr. Pascal Piller

https://www.invitro-connect.com/en - Your International Experts for Laboratory Testing and Regulatory Services - More than 80 test laboratories in our network - Product safety - Regulatory service - in vitro tests - All OECD tests for pharmaceuticals, chemicals, medical devices and cosmetics - in-house toxicologistes - Preclinical Services - Project management - Study monitoring --> complete services - all from one hand !!! --> contact@invitro-connect.com We would like to manage also your projects. Best regards Dr. Ute Hassmann (Deputy Managing Director) and Pascal Piller (Managing Director) INVITRO-CONNECT GmbH #biocides #toxicological #chemicals #laboratory #regulatory #affairs #reach #projectmanagement #pharma #medical #study #devices #Labor #GLP #cosmetics

Laboratory high pressure reactor system Reactor volume: 0.1 - 1.0 liter Pressure: -1 (FV) to +200 bar Temperature: -20 °C to +300 °C Material: stainless steel, Hastelloy® Other materials, pressures & temperatures are available This high pressure reactor system is designed for the use of interchangeable steel pressure vessels. Safety features guarantee safe reactions under pressure. The stainless steel or Hastelloy reactors ensure high resistance against acids. Visual process control and monitoring is also possible under high pressure by using steel pressure vessels with sight glasses. Various low to high torque magnetic drives ensure efficient mixing and stirring low to high viscosity process media as well as excellent heat transfer. The fast action closure and vessel lift makes changing vessels quick and easy without the use of tools. The modular setup of the midiclave system allows changing or upgrading for new tasks at any time.

Laboratory pressure reactor system / Stirred autoclave for chemical research Reactor volume: 100 to 300 ml Pressure: -1 (FV) to +10 bar / 100 bar Temperature: -20 °C to +200 / 300 °C Material: Borosilicate glass 3.3, stainless steel, Hastelloy®, PTFE Other materials, pressures & temperatures are available This pressure reactor system is designed for the use of interchangeable pressure vessels in glass, steel, Hastelloy®, Teflon. Safety features guarantee safe reactions under pressure. The glass pressure reactors ensure high resistance against acids, while allowing visual process control and monitoring.

Laboratory pressure reactor system - easy operation for heavy pressure vessels Reactor volume: 0.5 to 20.0 liter Pressure: -1 (FV) to +60 / 200 bar Temperature: -20 °C to +250 °C Material: stainless steel, Hastelloy®, glass-lined steel Other materials, pressures & temperatures are available This multipurpose pressure reactor system is designed for the use of large steel pressure vessels. The hydraulic vessel lift with tilt function makes opening and closing as well as cleaning of the vessel very easy. Safety features guarantee safe reactions under pressure. The stainless steel or Hastelloy® reactors ensure high resistance against acids. Visual process control and monitoring is also possible under high pressure by using steel pressure vessels with sight glasses. Various low to high torque magnetic drives ensure efficient mixing and stirring low to high viscosity process media as well as excellent heat transfer.

Glass-lined steel reactor: 250 - 10'000 liter Pressure: -1.0 (FV) to +0.5 bar Temperature: -60 °C (-90 °C) to +200 °C Material: Borosilicate glass 3.3, glass-lined steel, PTFE, PFA, tantalum Chemical process equipment consisting of glass-lined reactors or mixing tanks with distillation overhead in borosilicate glass can be operated at full vacuum and low pressure. A large variety of chemicals can be processed in such plants due to the highly corrosion resistant materials used. The design varies between multipurpose product / process specific set ups. Feeders and receivers are made of glass for smaller units and of glass lined steel for larger setups. Shell and tube type heat exchangers are built with inner tubes made of borosilicate glass, glass-lined steel, silicon carbide, tantalum or other metals depending on process parameters and other requirements.

Metal vessel: 5, 10, 20 liter Pressure: -1.0 (FV) to +6.0 bar Temperature: -10 °C to +200 °C Filter: sintered 8 to 115 micron Material: stainless steel, Hastelloy® C22 These robust and compact pressure filters are designed for filtration, pressurizing the vessel with up to 6 bar pressure. They offer a removable filter basket, a quick opening / closing system and a perfect fit to Buchi pressure reactors, allowing for an easy operation. The filter vessel is jacketed and can be temperature controlled by a circulator. Process connections are standard Tri-Clamp configuration.

Glass vessel: 30 liter Pressure: -1.0 (FV) to +0.5 bar Temperature: -60 °C to +200 °C Material: Glove made of EPDM For other materials and characteristics, see nutsche filters Buchi high containment nutsche filters allow for controlled filtration with a contained discharge by wiping out with a contained discharge by wiping out with the fixed glove (made of EPDM) into a bag system. The purpose of this filter is controlled filtration with a contained discharge by wiping out with the fixed glove into a bag system. The filter vessel can easily be lifted, lowered and tilted due to its versatile and solid stand.

Laboratory high pressure / high temperature reactor (HPHT) Standard Version: Reactor volume: 100 - 600 ml Pressure: -1 (FV) to +400 bar Temperature: -20 °C to + 400 °C Material: stainless steel, (Hastelloy® +400 °C) High-Pressure Version: Reactor volume: 100 - 600 ml Pressure: -1 (FV) to +500 bar Temperature: -20 °C to + 500 °C Material: stainless steel, (Hastelloy® +400 °C) This is our new high pressure and high temperature HPHT (high pressure high temperature) autoclave novoclave. This high pressure reactor system is designed for processes involving high pressures and temperatures. Safety features guarantee safe reactions under highest pressure. Designed, manufactured, and tested according to PED, AD2000. The modular setup of the novoclave system allows for changing the vessel size from 100 ml up to 600 ml using the same cover plate and electric heating block. Vessels are available in the following volumes: 100, 200, 300, 450, 600 ml.

The LST-V steam sterilizers are designed for the sterilization of solid, porous and difficult to ventilate goods as well as for the decontamination of waste in laboratories. They meet the European Pressure Equipment Directive 97/23/EC and the DIN 58951-2 standard for equipment groups A, B, C, D1, D2 and E1. The steam sterilizer of the LST-V series with vertically running sliding doors is characterized by its compact and ergonomic design. The LST-V is universally applicable for: Waste Glassware Porous, vacuum-tight goods Liquids in open or closed containers Culture media Animal cages, food

Seamless quality control is becoming an ever important factor in competition. Micrographs are indispensable in the release of new crimp terminals and tools. The highly flexible and modular MicroLab 55 micrograph laboratory is a central part of modern quality engineering. The MicroLab 55 micrograph laboratory is designed for the most versatile application ranges and is ideally suited for this purpose. It enables micrographs to be produced for all types of crimps available on the market – both transverse section and longitudinal section. The above applies also to products such as PCBs or housings from outside the automotive sector. Extremely short processing times can be achieved thanks to the optimum arrangement of the individual modules. Reproducible sample preparation is guaranteed to be perfect because the sample does not have to be re-clamped between the individual processing steps.

Single instrument for simultaneous process density (specific gravity), viscosity and temperature measurement Compact form-factor for simple installation Real-time, stable, repeatable and reproducible measurements in Newtonian & non-Newtonian fluids Measures kinematic and dynamic viscosity All metal (316L Stainless Steel) construction Completely insensitive to mounting conditions Operational to 7500 psi (500 bar) and 575°F (300°C) Threaded, flanged and sanitary process fittings Easy to clean, no maintenance or re-configurations needed Scale across multiple locations/installs without application re-engineering