Laboratory for industry analyses - Import export

We carry out the following analyses on foodstuffs, organic materials and rinse water. DNA detection We detect the DNA of various plant and animal species for you using real-time PCR. DNA quantification Once a positive detection has been established, the DNA detected can be quantified for both plant and animal species. Meat traceability This test is used to compare the genetic profiles of two samples taken from an animal (for example an ear in the abattoir and meat in the supermarket). This is used to prove whether or not the samples come from the same individual animal. Identification We use sequencing and the bioinformatic analysis of certain genes to identify the bacteria, plant or animal species in a sample.

INVITRO-CONNECT GmbH offers various test strategies without animal testing for examining Eye Irritation / Eye damage hazard assessment. From standard regulatory hazard assessments to providing information on the degree of ocular irritation, to discriminating among extremely mild eye area products, INVITRO-CONNECT’ Study Monitors take the time to understand your specific goals and apply the most relevant, cost-effective strategies to achieve them. Tests for Eye Irritation / Eye damage hazard assessment in vitro: HET-CAM Assay BCOP: OECD 437 Isolated Chicken Eye Test: OECD 438 STE / Short Time Exposure (STE, OECD 491): Ocular Irritection EpiOcular & SkinEthic HCE Reconstructed human Cornea-like Epithelium (RhCE): OECD 492 For more information please contact INVITRO-CONNECT GmbH for assistance in developing specialized protocols for your test materials. INVITRO-CONNECT GmbH: Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com

INVITRO-CONNECT GmbH offers various test strategies without animal testing for examining Eye Irritation / Eye damage hazard assessment. From standard regulatory hazard assessments to providing information on the degree of ocular irritation, to discriminating among extremely mild eye area products, INVITRO-CONNECT’ Study Monitors take the time to understand your specific goals and apply the most relevant, cost-effective strategies to achieve them. Tests for Eye Irritation / Eye damage hazard assessment in vitro: HET-CAM Assay BCOP: OECD 437 Isolated Chicken Eye Test: OECD 438 STE / Short Time Exposure (STE, OECD 491): Ocular Irritection EpiOcular & SkinEthic HCE Reconstructed human Cornea-like Epithelium (RhCE): OECD 492 For more information please contact INVITRO-CONNECT GmbH for assistance in developing specialized protocols for your test materials. INVITRO-CONNECT GmbH: Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com

Determination of skin sensitization potential is a critical endpoint in the safety assessment of raw materials, chemicals, mixtures and formulations. Although the Guinea Pig Maximization Test (GPMT) and Local Lymph node assay (LLNA) have historically been used to address this adverse effect, in vitro assays have been developed and validated in order to replace these resource-intensive animal tests. INVITRO-CONNECT GmbH offers various test strategies without animal testing for examining skin sensitization: - Direct Peptide Reactivity Activation Assay (DPRA, OECD 442C) - ARE-Nrf2 Luciferase Keratinocyte Activation Test Method (OECD 442D) -Human Cell Line Activation Test (h-CLAT, OECD 442E) -Kinetic Direct Peptide Reactivity Assay (kDPRA) -Myeloid U937 Skin Sensitization Test (MUSST / U-SENS) -and more Fast Project Execution: personal - competent - reliable --> contact@invitro-connect. - More than 80 Test Laboratories - Product Safety - Regulatory Service -

INVITRO-CONNECT GmbH offers various test strategies without animal testing for examining skin Corrosion: - OECD 435 - Skin Corrosion : "In Vitro Membrane Barrier Test Method for Skin Corrosion" (Corrositex): The Corrositex® assay is a standardized and quantitative in vitro test developed as a replacement for the dermal corrosivity rabbit test. The Corrositex® assay is presently the only in vitro assay approved by the U.S. Department of Transportation for testing potential corrosive materials and assigning packing group categories. For more information please contact INVITRO-CONNECT GmbH for assistance in developing specialized protocols for your test materials. INVITRO-CONNECT GmbH: Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com More than 80 test laboratories - Product safety - Regulatory service - In vitro tests - All OECD tests for pharmaceuticals, chemicals, medical devices and cosmetics - Study monitoring, MSDS etc.

Material Safety Data Sheet - Hazardous Substances Advice and Hazardous Substance Management Overview of our services: - Check of conformity and plausibility as well as updating of existing Material Safety Data Sheets - Preparing of extended Material Safety Data Sheets - Classification and labelling of substances according to the current GHS regulation (CLP regulation) Depend on requirements INVITRO-CONNECT GmbH checks whether your existing safety data sheets are still compliant and plausible to follow latest REACH guidelines and if necessary, updates them for you. Furthermore, based on our know-how we provide extended material safety data sheet, following the REACH Directive as well as the latest European GHS regulation for classification and labelling of substances. INVITRO-CONNECT GmbH - Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com Best regards Pascal Piller and Dr. Ute Hassmann and the whole team of INVITRO-CONNECT GmbH

- OECD 439 / Skin Irritation Test (SIT) in a Reconstructed Human Epidermis (RhE) Model - Skin Irritation in the regulatory hazard classification and labeling context is defined as the production of reversible damage to skin following a defined chemical exposure. The Skin Irritation Test (SIT) is an in vitro, non-animal test designed to identify those chemicals and mixtures capable of inducing moderate skin irritation (UN GHS Category 2 Skin Irritants1), and to discriminate UN GHS Category 2 Skin Irritants from UN GHS 3 Mild Skin Irritants as well as those not requiring classification for skin irritation potential. INVITRO-CONNECT GmbH has extensive expertise with a wide variety of reconstructed skin-based protocols. For more information please contact INVITRO-CONNECT GmbH for assistance in developing specialized protocols for your test materials. INVITRO-CONNECT GmbH: Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com

Our laboratories are equipped to the highest standard to ensure we deliver high quality results for our clients. Our equipment includes: ICP-OES HPLC-MS/MS HPLC-UV HPLC-DAD HPLC-MS GC-FID GC/MS GC Headspace IC (Ion Chromatography) We also offer a range of physical testing equipment designed to meet the specifications of a large number of CIPAC/EEC/OECD methods and guidelines.