Laboratory analysis - Import export

We carry out the following analyses on foodstuffs, organic materials and rinse water. DNA detection We detect the DNA of various plant and animal species for you using real-time PCR. DNA quantification Once a positive detection has been established, the DNA detected can be quantified for both plant and animal species. Meat traceability This test is used to compare the genetic profiles of two samples taken from an animal (for example an ear in the abattoir and meat in the supermarket). This is used to prove whether or not the samples come from the same individual animal. Identification We use sequencing and the bioinformatic analysis of certain genes to identify the bacteria, plant or animal species in a sample.

The soil sample container is designed to provide a convenient and reliable solution for collecting and transporting soil samples for analysis in the laboratory. The cardboard box is 120x70x50 mm in size, providing ample space for the soil sample. It is easy and quick to fold without the need for staples, ensuring ergonomic work and saving time. The cardboard used is of high quality, ensuring the safe transport of the soil sample without any damage or contamination. With this soil sample container, you can confidently collect and transport soil samples for accurate analysis and reliable results.

INVITRO-CONNECT GmbH offers various test strategies without animal testing for examining Eye Irritation / Eye damage hazard assessment. From standard regulatory hazard assessments to providing information on the degree of ocular irritation, to discriminating among extremely mild eye area products, INVITRO-CONNECT’ Study Monitors take the time to understand your specific goals and apply the most relevant, cost-effective strategies to achieve them. Tests for Eye Irritation / Eye damage hazard assessment in vitro: HET-CAM Assay BCOP: OECD 437 Isolated Chicken Eye Test: OECD 438 STE / Short Time Exposure (STE, OECD 491): Ocular Irritection EpiOcular & SkinEthic HCE Reconstructed human Cornea-like Epithelium (RhCE): OECD 492 For more information please contact INVITRO-CONNECT GmbH for assistance in developing specialized protocols for your test materials. INVITRO-CONNECT GmbH: Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com

INVITRO-CONNECT GmbH offers various test strategies without animal testing for examining Eye Irritation / Eye damage hazard assessment. From standard regulatory hazard assessments to providing information on the degree of ocular irritation, to discriminating among extremely mild eye area products, INVITRO-CONNECT’ Study Monitors take the time to understand your specific goals and apply the most relevant, cost-effective strategies to achieve them. Tests for Eye Irritation / Eye damage hazard assessment in vitro: HET-CAM Assay BCOP: OECD 437 Isolated Chicken Eye Test: OECD 438 STE / Short Time Exposure (STE, OECD 491): Ocular Irritection EpiOcular & SkinEthic HCE Reconstructed human Cornea-like Epithelium (RhCE): OECD 492 For more information please contact INVITRO-CONNECT GmbH for assistance in developing specialized protocols for your test materials. INVITRO-CONNECT GmbH: Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com

INVITRO-CONNECT GmbH offers various test strategies without animal testing for examining skin Corrosion: - OECD 435 - Skin Corrosion : "In Vitro Membrane Barrier Test Method for Skin Corrosion" (Corrositex): The Corrositex® assay is a standardized and quantitative in vitro test developed as a replacement for the dermal corrosivity rabbit test. The Corrositex® assay is presently the only in vitro assay approved by the U.S. Department of Transportation for testing potential corrosive materials and assigning packing group categories. For more information please contact INVITRO-CONNECT GmbH for assistance in developing specialized protocols for your test materials. INVITRO-CONNECT GmbH: Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com More than 80 test laboratories - Product safety - Regulatory service - In vitro tests - All OECD tests for pharmaceuticals, chemicals, medical devices and cosmetics - Study monitoring, MSDS etc.

Material Safety Data Sheet - Hazardous Substances Advice and Hazardous Substance Management Overview of our services: - Check of conformity and plausibility as well as updating of existing Material Safety Data Sheets - Preparing of extended Material Safety Data Sheets - Classification and labelling of substances according to the current GHS regulation (CLP regulation) Depend on requirements INVITRO-CONNECT GmbH checks whether your existing safety data sheets are still compliant and plausible to follow latest REACH guidelines and if necessary, updates them for you. Furthermore, based on our know-how we provide extended material safety data sheet, following the REACH Directive as well as the latest European GHS regulation for classification and labelling of substances. INVITRO-CONNECT GmbH - Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com Best regards Pascal Piller and Dr. Ute Hassmann and the whole team of INVITRO-CONNECT GmbH

Material Safety Data Sheet - Hazardous Substances Advice and Hazardous Substance Management Overview of our services: - Check of conformity and plausibility as well as updating of existing Material Safety Data Sheets - Preparing of extended Material Safety Data Sheets - Classification and labelling of substances according to the current GHS regulation (CLP regulation) Depend on requirements INVITRO-CONNECT GmbH checks whether your existing safety data sheets are still compliant and plausible to follow latest REACH guidelines and if necessary, updates them for you. Furthermore, based on our know-how we provide extended material safety data sheet, following the REACH Directive as well as the latest European GHS regulation for classification and labelling of substances. INVITRO-CONNECT GmbH - Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com Best regards Pascal Piller and Dr. Ute Hassmann and the whole team of INVITRO-CONNECT GmbH

INVITRO-CONNECT GmbH is your ideal partner and service provider for your projects in the field of life science for chemicals / REACH, pharmaceuticals, biocides, cosmetics and medical devices. We are the strong partner at your side who provides our tailor-made service modules according to your project requirements. You have the choice to individually select the modules that you urgently need in your projects from our modular service system. With our technical expertise and our customer-oriented approach, we fit in perfectly with your projects and processes, so that we form a team and nothing stands in the way of the project's success. The Modules can be individually and flexibly adapted for each project. For more information please contact INVITRO-CONNECT GmbH. INVITRO-CONNECT GmbH - Your International Experts for Laboratory Testing and Regulatory Services Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com

Testing against enveloped viruses as a replacement for the currently unavailable commercial test strategy against 2019-nCov / SARS-CoV-2 Since the new SARS-CoV-2 virus is one of the enveloped viruses, INVITRO-CONNECT GmbH offers testing of various surfaces and disinfectants against the Vaccinia Ankara Virus (MVA) as a reference virus for enveloped viruses, as well as against the bovine coronavirus , which, like SARS-CoV-2, belongs to the genus Betacoronavirus. In addition to standard tests for surfaces in accordance with ISO 21702 (smooth surfaces) and ISO 18184 (rough surfaces) as well as suspension tests for the disinfectant area (EN ISO 14476/16777), other tests are also offered on request (see below). Named tests are currently the state-of-the-art test methods for testing against 2019-nCov / SARS-CoV-2, as there is currently no specific test procedure against the 2019-nCov / SARS-CoV-2 virus itself. For more information --> contact@invitro-connect.com

Microbiological examinations / Microbiological tests against viruses, bacteriophages, bacteria, yeast, molds, mycobacteria and bacterial spores for disinfectants, medical devices, pharmaceutical products and cosmetics Our team of experts supports manufacturers of biocidal and medical products as well as cosmetics and pharmaceuticals scientifically in the context of approval projects. For example, we create safety assessments for cosmetics and biocompatibility assessments for medical devices. Here we focus in particular on infection prevention and wound treatment products. For more information please contact INVITRO-CONNECT GmbH for assistance in developing specialized protocols for your test materials. INVITRO-CONNECT GmbH: Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com

- in vitro gene mutation study in bacteria: Ames Test OECD 471 - in vitro gene mutation study in mammalian cells: Mouse Lymphoma Assay (MLTK Assay) OECD 490 - in vitro gene mutation study in mammalian cells: HPRT test / OECD 476 - Micronucleus Assay in vitro (Human Lymphocytes or V79 cells) / OECD 487 - Chromosomal aberration Assay in vitro (Human Lymphocytes or V79 cells) / OECD 473 - Hen’s Egg Test – Induction of Micronuclei (HET-MN) - COMET Assay in different cell types - Cell Transformation Assay in Bhas Cells / OECD 231 (draft) - Mammalian Erythrocyte Micronucleus Test / OECD 474 / ISO 10993-3 - Combined Mammalian Erythrocyte Micronucleus Test with concurrent Alkaline Comet Assay in vivo OECD 474 & 489 - In vivo Mammalian Alkaline Comet Assay / OECD 489 - Unscheduled DNA synthesis (UDS) Test with Mammalian Liver Cells in vivo / OECD 486 - Mammalian Spermatogonial Chromosomal Aberration test / OECD 483 - Mammalian Bone Marrow Chromosomal Aberration test / OECD 475

- OECD 439 / Skin Irritation Test (SIT) in a Reconstructed Human Epidermis (RhE) Model - Skin Irritation in the regulatory hazard classification and labeling context is defined as the production of reversible damage to skin following a defined chemical exposure. The Skin Irritation Test (SIT) is an in vitro, non-animal test designed to identify those chemicals and mixtures capable of inducing moderate skin irritation (UN GHS Category 2 Skin Irritants1), and to discriminate UN GHS Category 2 Skin Irritants from UN GHS 3 Mild Skin Irritants as well as those not requiring classification for skin irritation potential. INVITRO-CONNECT GmbH has extensive expertise with a wide variety of reconstructed skin-based protocols. For more information please contact INVITRO-CONNECT GmbH for assistance in developing specialized protocols for your test materials. INVITRO-CONNECT GmbH: Fast Project Execution: personal - competent - reliable --> contact@invitro-connect.com

Determination of skin sensitization potential is a critical endpoint in the safety assessment of raw materials, chemicals, mixtures and formulations. Although the Guinea Pig Maximization Test (GPMT) and Local Lymph node assay (LLNA) have historically been used to address this adverse effect, in vitro assays have been developed and validated in order to replace these resource-intensive animal tests. INVITRO-CONNECT GmbH offers various test strategies without animal testing for examining skin sensitization: - Direct Peptide Reactivity Activation Assay (DPRA, OECD 442C) - ARE-Nrf2 Luciferase Keratinocyte Activation Test Method (OECD 442D) -Human Cell Line Activation Test (h-CLAT, OECD 442E) -Kinetic Direct Peptide Reactivity Assay (kDPRA) -Myeloid U937 Skin Sensitization Test (MUSST / U-SENS) -and more Fast Project Execution: personal - competent - reliable --> contact@invitro-connect. - More than 80 Test Laboratories - Product Safety - Regulatory Service -

https://www.invitro-connect.com/en - Your International Experts for Laboratory Testing and Regulatory Services - More than 80 test laboratories in our network - Product safety - Regulatory service - in vitro tests - All OECD tests for pharmaceuticals, chemicals, medical devices and cosmetics - in-house toxicologistes - Project management - Study monitoring --> complete services - all from one hand !!! --> contact@invitro-connect.com We would like to manage also your projects. Best regards Pascal Piller and the whole team of INVITRO-CONNECT GmbH #biocides #toxicological #chemicals #laboratory #regulatory #affairs #reach #projectmanagement #pharma #medical #study #devices #Labor #GLP #cosmetics

Our Gas Quality Competence Centre answers chemical analysis and process engineering questions in all matters connected with the transportation and use of natural gas. Our Competence Centre uses high-performance methods and processes for the analysis of gases and accompanying substances and can draw on many years of experience in the operation of our transmission system and cooperation with customers. The full range of our laboratory services if of course also available to other companies and organisations. They include: Determination of natural gas compositions in accordance with DVGW Code of Practise G 260 Natural gas analyses up to C14 Determination of trace concentrations of accompanying substances Water analyses on preheaters in accordance with DVGW Code of Practise G 495 Natural gas safety data sheet and much more Our Gas Quality Competence Centre is certified to DIN EN ISO 9001. The natural gas analysis laboratory is accredited to DIN EN ISO/IEC 17025.

Our experts provide detailed laboratory analysis of the product, prepare documentation and dossier

Water analysis Drinking water investigation (TVO, Kalkaggressivität DIN 50930) microbiological examinations accredited sampling and analytics Basic and raw water investigations with identification of the ion balance limnological and marine sampling and testing Leachate investigations in the landfill area Operational monitoring of sewage treatment plants Operation monitoring of waterworks sewage sludge analyzes Investigation of concrete aggressiveness according to DIN 4030 Waste and recycling Examination of pollutants and expert support of dismantling of buildings and technical installations Site coordination by experts for safety and health protection when working in the contaminated area according to DGUV Rule 101-004 (formerly BGR 128) Health and safety plans for work in the contaminated area Emission monitoring of landfill sites (groundwater monitoring, leachate investigations, gas emission measurements, soil monitoring.

How practically feasible or realistic is an idea? Sirris can help you find out, and not just by offering advice. All the innovative solutions we develop together with you are also put to the test in an industrial setting, either on your behalf or in conjunction with you. Our high-tech infrastructure will always enable you to find out exactly where you stand. A few examples of our infrastructure A metal machining centre, guaranteeing micron precision Europe's largest climate chamber Cobots deployed in a flexible, robotised, machining cell Europe's most highly diversified additive manufacturing machine park Hybrid PVD or HiPIMS and aerosol jet printing Microproduction (machining, EDM, injection moulding , etc.). An application lab for Incremental Sheet Forming (ISF) Testing laboratories for materials & products analysis...

Our laboratories are equipped to the highest standard to ensure we deliver high quality results for our clients. Our equipment includes: ICP-OES HPLC-MS/MS HPLC-UV HPLC-DAD HPLC-MS GC-FID GC/MS GC Headspace IC (Ion Chromatography) We also offer a range of physical testing equipment designed to meet the specifications of a large number of CIPAC/EEC/OECD methods and guidelines.

Waste & recycling Examination of pollutants & expert support of dismantling of buildings & technical installations Site coordination by experts for safety & health protection when working in the contaminated area according to DGUV Rule 101-004 (formerly BGR 128) Health & safety plans for work in the contaminated area Emission monitoring of landfill sites (groundwater monitoring, leachate investigations, gas emission measurements, soil monitoring) Contaminated sites & claims Collection, exploration & evaluation of old sites, old deposits & claims Renovation management & support Site coordination by experts for safety & health protection when working in the contaminated area according to DGUV Rule 101-004 (formerly BGR 128) Aftercare concepts & examinations (eg groundwater monitoring) Inspection/quality control Inspection of the production & storage of wood pellets Quality assurance concepts & monitoring of secondary fuels and waste wood Supervision of biogas