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R427A, also known as Forane® 427A, is an HFC blend. It is a non-toxic, non-flammable, zero-ODP (Ozone Depletion Potential) refrigerant. R427A has the lowest GWP of R22 retrofit replacement refrigerants. All fluorocarbon refrigerant gases contain one or more carbon and fluorine atoms and are organic compounds. Atoms of chlorine, hydrogen and bromine may also be present.