Age spots - Import export

Senile lentigo or solar lentigines, also called age spots, are brown, grey or black spots located on the skin. They appear on areas of the body frequently exposed to the sun and are generally associated with skin ageing. Disturbed releases of growth factors are involved in the excessive proliferation of keratinocytes and production of melanin, characteristic of these types of lesions. StratiCELL has developed a unique in vitro RHE model of solar lentigines based on specific culture conditions that induce hyperproliferation of the epidermis as well as an increase in pigmentary lesions with histological similarity to in vivo observations. This model is a powerful tool for assessing the efficacy of compounds aimed at reducing age spots or improving their appearance.

StratiCELL has an innovative device to show the pigmenting effect of a product on the macroscopic appearance of pigmented skin reconstructed in vitro, comparable to a clinical trial. High definition pictures are taken during or at the end of treatments and the device generates an automatic calculation of the individual typology angle (ITA), the pigmentation index (PI), and the colorimetric contrast (ΔC) of the skin. StratiCELL can also performed melanin content quantification (Solvable®), melanin staining (Fontana Masson) and immunolabelling of key biomarkers (TYRP1, MART1, etc.).Because the skin pigmentation process is more complicated than a simple synthesis of melanin, each of our pigmented skin models (3D) perfectly reproduces the complex and dynamic environments of cell interactions encountered “in vivo”. Our models include: Light to dark skin models with the photo-type of your choice Age Spots skin models Asian skin models and other ethnicities