Enzalutamide binds to androgen receptors and thereby inhibits them (antiandrogen). In addition, translocation in the cell nuclei is inhibited and the binding to the DNA is weakened, as well as the recruitment of cofactors for transcription. This leads to the inhibition of gene expression, which are regulated by the androgen receptors. Due to the triple mechanism of action, Enzalutamide differs from the usual anti-androgenic substances. Due to its anti-androgenic properties, the active ingredient also has an antineoplastic effect in androgen-sensitive tumors (e.g. metastatic prostate cancer).
MIDAS PHARMA GMBH
Germany
Sodium Borohydride is a versatile and selective reducing agent that has a variety of applications in manufacturing of pharmaceutical active ingredients, crop protection agents, aroma compounds and other fine chemicals. Its CAS-N° reads [16940-66-2]. Typical applications are: Reduction of Aldehydes / Acid Chlorides / Anhydrides to primary Alcohols; Reduction of Ketones to secondary Alcohols; Reduction of Imines to Amines; Removing impurities and purification of process streams; Metal ion reduction / Noble metal recovery / Dehalogenations. Sodium Borohydride is due to its reactivity a hazardous compound under dangerous goods regulation which requires specific storage. Our material is usually promptly available from stock for industrial consumers, To influence reactivity and handling comfort the product is available as coarse powder, fine powder and as granules. Detailed specification, material safety data sheet and additional documents are available on request.
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Germany
Diethylpropion hydrochloride is an amphetamine derivative that acts systemically on the cardiovascular system, certain organs and the brain (or CNS) as an indirect α-sympathomimetic. It is counted among the psychostimulants and suppresses needs such as sleep, appetite, thirst and urination. The release of catecholamines (e.g. adrenaline, dopamine) increases heart rate, blood pressure and pulmonary circulation. It is used to treat obesity.
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Germany
Pipamperone 2HCl is an active pharmaceutical ingredient manufactured following the EU-GMP regulations. We offer the API following EU-GMP (ICH Q7) regulations with an active ASMF. Material is availalbe upon request from stock. The active ingredient is used as an antipsychotic and sedative. It works mainly on the serotonin and dopamine receptors. The sedative effect outweighs that of the antipsychotic. Pipamperone regulates internal restlessness, sleep disturbances, and also weakens arousal conditions, as well as aggressiveness.
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Germany
Ketoprofen is a synthetically synthesized Active Pharmaceutical Ingredient, produced under cGMP, compliant with EP, JP monographs. Its CAS-N° reads 22071-15-4. It is used in treatment of arthritis-related inflammatory pains, severe toothaches that result in the inflammation of the gums or nerve pain. Ketoprofen is an acidic, non-opioid analgesic used for pain and inflammation. By inhibiting prostaglandin synthesis at the key enzyme cyclooxygenase, it can be used for acute and chronic pain (e.g. arthrosis and arthritides). Like most active ingredients in its class, it is poorly tolerated by the gastrointestinal tract, a particular side effect is light sensitization. Detailed specification, Certificate of Analysis and samples are available on request.
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